Unikalne działanie

Wyjątkowa konstrukcja preparatu GAF™ łączy w sobie z jednej strony zalety Mikronizowanego Srebra, jako doskonałej alternatywy dla antybiotykoterapii, likwidując stan zapalny poprzez ograniczenie namnażania się bakterii i ich niszczenie, z drugiej zaś wykorzystuje właściwości przyspieszające proces gojenia Kwasu Hialuronowego oraz jego mukoadhezyjność utrzymując proces leczenia w ciągłym działaniu i zmniejszając zużycie preparatu. Wszystkie zalety obu technologii, które łączy w sobie GAF™ opisuje poniższa grafika.

Referencje

  • Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Prabhu et al. International Nano Letters. 2012:2-32
  • Antimicrobial Polymers with Metal Nanoparticles. Humberto Palza. Int. J. Mol. Sci. 2015;16: 2099-2116
  • Antimicrobial activities of silver used as a polymerization catalyst for a wound-healing matrix. Babu et al. Biomaterials. 2006 Aug;27(24):4304–4314
  • Methanogens and Nano-Silver. James Ferry - Stanley Person Professor of Molecular Biology. http://methanenanosilver.weebly.com/index.html
  • Body care product containing porous silver particles. Patent number US20070081958A1.
  • Natural silver for the skin. www.cossma.com
  • What is Microsilver. www.silvaclear.com/what-is-microsilver/
  • Antibacterial activity and mechanism of silver nanoparticles on Escherichia coli. W-r Li et al. Appl Microbiol Biotechnol (2010) 85:1115-1122
  • Hyaluronic acid and skin: wound healing and aging. Manuskiatti et al. International Journal of Dermatology. 1996 Aug;35(8):539–544
  • The efficacy of topical hyaluronic acid in the management of oral lichen planus. Nolan et al. J. Oral Pathol Med. 2009;38:299-303
  • Hyaluronic acid hydrogels for vocal fold wound healing. Gaston et al. Biomatter. 2013 January 1;3(1):23799
  • Methods of treating hemorrhoids and anorectal disease – Patent number US5234914 A
  • Hyaluronan: A Simple Polysaccharide with Diverse Biological Functions. Dicker et al. Acta Biomater. 2014 April; 0(4):1558–1570
  • Healing of burn wounds by topical treatment: a randomized controlled comparison between silver sulfadiazine and non-crystalline silver. Adhya et al. J. Basic and Clinical Pharmacy. 2015 Dec-Feb (1);6:29-34
  • Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia Coli. W. Kyung Jung et al. Applied and Environmental Microbiology, Apr. 2008, 2171-2178
  • Silver colloidal nanoparticles: antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata. D.R. Monteiro. Biofouling Vol.27, No. 7, August 2011, 711-719
  • The effect of silver ions and silver nanoparticles on Staphylococcus aureus. D. Chudobova et al. Microbial pathogens and strategies for combatting them: science, technology and education, Formatex 2013
  • A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. Q.L. Feng et al. John Wiley & Sons, 2000
  • Complexes of Silver(I) Ions and Silver Phosphate Nanoparticles with Hyaluronic Acid and/or Chitosan as Promising Antimicrobial Agents for Vascular Grafts. D. Chudobova et al. International Journal of Molecular Sciences 2013, 14, 13592-13614
  • Bactericidal effect of silver nanoparticles against multidrug-resistant bacteria. H.H. Lara et al. World J. Microbiol Biotechnol (2010) 26:615-621
  • The Application of Bactericidal Silver Nanoparticles in Wound treatment. G. Nam et al. Nanomaterials and Nanotechnology, 2015,5:23
  • Effect of Silver Nanoparticles Solution on Staphylococcus aureus and Candida spp. A.F. Wady et al. Journal of Nanomaterials, Volume 2014, Article ID 545279
  • Colloidal Silver as a New Antimicrobial Agent. N.H.Assar et al. International Journal of Microbiological Research 1 (1) : 33---36, 2010
  • Antifungal Effect of Silver Nanoparticles on Dermatophytes. K. Keuk-Jun et al. J Microbiol Biotechnol (2008), 18(8), 1482-1484
  • Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study. H.H. Lara et al. Journal of Nanobiotechnology 2015, 13:91.
  • Hyaluronian in wound healing: rediscovering a major player. Aya et al. Wound Repair Regen. 2014;Sep-Oct,22(5):579-93
  • Hyaluronic acid: the scientific and clinical evidence. Price et al. J. Plast. Reconstr Aesthet Surg. 2007;60(10):1110-9
  • Use of Silver PhosphateNanoParticles (SPNPs) for their antimicrobial effect on bacterial strains. D. Chudobova et al. NANOCON 2013
  • Impaired wound healing in diabetes: the rationale for clinical use of hyaluronic acid plus silver sulfadiazine. M. Prosdocimi et al. Minerva Medica 2012; 103:533-9
  • Second-degree burns: a comparative, multicentre, randomized trial of hyaluronic acid plus silver sulfadiazine alone. M. Costagliola et al. Current Medicalresearch and Opinion, Vol. 21, N°8, 2005, 1235-1240
  • Topical treatment of partial thickness burns by silver sulfadiazine plus hyaluronic acid compared to silver sulfadiazine alone: a double-blind, clinical study. Koller, J et al. Drugs Exptl. Clin Res, 183-190 (2004)
  • Olczyk P. i wsp. Hialuronian – struktura, metabolizm, funkcje i rola w procesach gojenia ran. Postępy Hig Med Dosw 2008; 62: 651-9

Informacje dodatkowe

  • Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Echerichia coli. Woo et al. Applied and Environmental Microbiology. 2008 April:2171-8
  • Antimicrobila polymers with metal nanoparticles. Humberto Palza. Int. J. Mol. Sci. 2015;16:2099-2116
  • Healing of burn wounds by topical treatment: a randomized controlled comparison between silver sulfadiazine and non-crystalline silver. Adhya et al. J. Basic and Clinical Pharmacy. 2015 Dec-Feb (1);6:29-34
  • Antimicrobial adhesive and coating substance and method for the production thereof. Patent number US7476698B2
  • Hyaluronan and wound healing: a new perspective. Ritz et al. Brit J Plast. Surg. 1991;44(8):579-57
  • Fibronectin functional domains coupled to hyaluronian stimulate adult human dermal fibroblast responses critical for wound healing. Ghosh et al. Tissue Eng. 2006 Mar;12(3):601-13
  • Hemorrhoids and varicose veins: a review of treatment options. Mackay D. Altern Med Rev. 2001 Apr;6(2):126--40

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